Emanuele Scalone
Email: emanuele.scalone@unimi.it
Cicle: XXXV A.Y. 2019 - 2020
Supervisor: Carlo Camilloni
Title: Molecular modelling of biomolecular self-assembly processes … read more

External links: ResearchGate ORCID Linkedin


Curriculum vitae: >>>


PhD Seminars:

Date	Title	Speakers
04/10/2019	Molecular Mechanism of Nucleosome Recognition	Chiara Marabelli
08/11/2019	Knotted Proteins Through the Looking Glass	Shang-Te Danny Hsu
12/11/2019	Unveiling RNA Polymerase III (extra) Transcriptional Complexes with EM	Alessandro Vannini
14/11/2019	Structural Joint Lab Meeting	Flavio di Pisa
18/01/2020	The Double Life of the Apoptosis Inducing Factor (AIF): the pro-survival function of a pro-death protein	Paolo Cocomazzi
24/01/2020	In Quest of a Thermosensor in Ion Channels	Cristina Arrigoni
21/02/2020	Visualization of Structural Data: much more than pretty structures	Monica Zoppé
01/04/2020	Decoding the non coding: the small, the Long and the Antisense	Paolo Gandellini
22/04/2020	Computational Structural Biology @UniMi: what we can learn from how proteins move	Carlo Camilloni
06/05/2020	Architecture and Dynamics of Macromolecules Revealed by Cryo-Electron Microscopy	Paolo Swec
16/05/2020	Early Steps in Amyloid Assembly: The Achilles Heel of a Disease Mechanism	Sheena Radford
06/06/2020	Computational Microscopy of SARS-COV2	Rommie Amaro
30/07/2020	The Proteins' Sugar Coat: a General Introduction with Insight into the Structure and Function of SARS-COV2 S glycan shield	Elisa Fadda
25/09/2020	FAM64C and FNDC3A are Multiple Myeloma Tumor Suppressor that Act in Concert to Impair Clearing of Protein Aggregates and Autophagy	Nicola Manfrini
04/11/2020	Defining Novel Mechanisms in Angiotensin	Alessandro Fantin
19/11/2020	Rational Design of Conformation Specific Antibodies Targeting Protein Aggregates	Michele Vendruscolo
27/11/2020	GPCRmd Brings G-protein-coupled Receptor into Motion	Jena Selent
12/01/2021	CURLI - Structure, Function and Application of a Bacterial Amyloid Pathology	Han Remaut
21/01/2021	Pandemie Antiche e Interpretazioni Moderne	Arnaldo Marcone
21/01/2021	Le Origini delle Epidemie	Paolo Mazzarello
03/02/2021	Human Mical 1, the Novel Fluoroenzyme Participating in Actin Cytoskeleton Dynamics	Maria Antonietta Vanoni
04/02/2021	Covid-19: tra Infodemia e Pandemia	Giovanni Maga
18/02/2021	Unveiling Cardiac Disease Pathophysiology: IPSC as a New Tool	Patrizia Benzoni
18/03/2021	Covid-19: lo Stato della Pandemia	Massimo Galli
18/03/2021	Soppressioni di un Focolaio di SARS-COV2 nel Comune Italiano di Vó	Andrea Crisanti
05/05/2021	Studying the Molecular Bases of Light Chain Amyloidosis	Stefano Ricagno
20/05/2021	Guanylate Cyclase Activating Protein 1 Monomer-Dimer Equilibrium Controlled by Ca2+ and Mg2+ Binding: Hints to Understand Retinal Guanylate Cyclase	Francesco Bonì
18/06/2021	Misfolded Glycoprotein Recognition in the ER: Does it Take one to Know One?	Pietro Roversi
18/01/2022	Why Do We Have 1 Head, 2 Arms and 2 Legs?	Neil Vargesson
22/03/2022	Interactions Dynamics of Intrinsically Disordered Proteins from Single-Molecule Spectroscopy	Ben Schuler
04/05/2022	Machine Learning for Molecular Simulation - from Quantum Chemistry to Protein Dynamics	Frank Noé
28/10/2022	Accurate modeling DNA deformability and its role in protein binding	Prof. Martin Zacharias
04/11/2022	Harnessing the Power of Computer Graphics for Structural Biology with Blender Molecular Nodes	Brady Johnston

PhD Courses:

Starting Date	Ending Date	Title	Place
21/11/2019	22/11/2019	Exploratory data analysis in R	Bioscience Department
21/11/2019	22/11/2019	Workshop on Exploratory Data Analysis in R	Milano
03/12/2019	03/12/2019	Convegno Assolombarda	Assolombarda
03/02/2020	07/02/2020	Methods and communication of the results	Bioscience Department
31/03/2020	31/03/2020	Communication on New Media	Bioscience Department
02/05/2020	02/07/2020	Introduction to Python programming	CINECA
23/06/2020	25/06/2020	INTRODUCTION TO TRANSCRIPTOMIC DATA ANALYSIS	University of Milan
21/09/2020	21/09/2020	VIROLOGY: NEW ADVANCES IN BASIC AND APPLIED RESEARCH	University of Milan
13/01/2021	27/01/2021	BIOSTATISTICS FOR MOLECULAR AND CELLULAR BIOLOGY	University of Milan
27/04/2021	27/04/2021	SCIENTIFIC VISUALIZATION OF MOLECULAR PROCESSES IN THE CELLULAR ENVIRONMENT	University of Milan
13/09/2021	15/09/2021	MODERN IMAGING TECHNIQUES IN BIOLOGY	University of Milan

Conferences / Workshops:

Starting Date	Ending Date	Title	Place
16/07/2022	17/07/2022	Gordon Research Seminar on Computational Chemistry	Castelldefels, Barcelona, Spain
17/07/2022	22/07/2022	Gordon Research Conference on Computational Chemistry	Castelldefels, Barcelona, Spain
05/10/2022	08/10/2022	Physics of Biomolecules: Structure, Dynamics and Function	Bressanone, Bolzano, Italia

Abroad experiences:

Starting Date	Ending Date	Project	Institution	Supervisor
07/03/2022	31/05/2022	Further development of Multi-eGO	University of Cambridge	Michele Vendruscolo

Publications:

 The structure of N184K amyloidogenic variant of gelsolin highlights the role of the H-bond network for protein stability and aggregation properties
Matteo de Rosa, Alberto Barbiroli, Francesco Bonì, Emanuele Scalone, Davide Mattioni, Maria A. Vanoni, Marco Patrone, Michela Bollati, Eloise Mastrangelo, Toni Giorgino, Mario Milani
European Biophysics Journal

 High-resolution crystal structure of gelsolin domain 2 in complex with the physiological calcium ion.
Michela Bollati, Emanuele Scalone, Francesco Bonì, Eloise Mastrangelo, Toni Giorgino, Mario Milani, Matteo de Rosa
Biochemical and Biophysical Research Communications

 Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis
Muzio L, Sirtori R, Gornati D, Eleuteri S, Fossaghi A, Brancaccio D, Manzoni L, Ottoboni L, Feo L, Quattrini A, Mastrangelo E, Sorrentino L, Scalone E, Comi G, Marinelli L, Riva N, Milani M, Seneci P
Nat Commun.

 Inactivation of the Pyrimidine Biosynthesis pyrD Gene Negatively Affects Biofilm Formation and Virulence Determinants in the Crohn’s Disease-Associated Adherent Invasive Escherichia coli LF82 Strain
Rossi Elio, Gabriella Leccese, Valerio Baldelli, Alessia Bibi, Emanuele Scalone, Carlo Camilloni, Moira Paroni, and Paolo Landini
Microorganisms

 Multi-eGO: An in silico lens to look into protein aggregation kinetics at atomic resolution
Emanuele Scalone, Luca Broggini, Cristina Visentin, Davide Erba, Fran Bacic Toplek, Kaliroi Peqini, Sara Pellegrino, Stefano Ricagno,Cristina Paissoni, and Carlo Camilloni
PNAS