Research Project Summary XLI CYCLE – A.Y. 2025-2026
Project leader: Camilla Betti
Proximity proteomics to untangle photoperiodic regulation of flowering in rice
Project leader: Stefano Biffo
Ribosome recycling in tumor cells
Project leader: Federica Briani
Development of strategies aimed to the correction of human PNPase defects
Project leader: Annalisa Bucchi
Molecular basis of cardiac arrhythmias
Project leader: Carlo Camilloni
Data driven modelling of biomolecular self-assembly processes
Project leader: Giuseppina Caretti
Investigating the role of PERM1 in transcriptional regulation of oxidative metabolism, in Duchenne Muscular Dystrophy
Project leader: Elena Cattaneo
Decoding stem cell transplants in HD through barcoding and single-cell analysis
Project leader: Elena Cattaneo
Mapping cholesterol’s therapeutic efficacy in Huntington’s Disease via spatially resolved analysis of the cortico-striatal synapse
Project leader: Matteo Chiara
Development of bioinformatics methods for the annotation and classification of transcriptional isoforms from single molecule transcriptome sequencing
Project leader: Lucia Colombo
Unraveling the molecular regulatory mechanisms controlling the development of female germline in plants
Project leader: Lucio Conti
Harnessing Natural Variation in Water Deficit Responses: Unveiling the Molecular Links Between Drought Adaptation and Life History Traits
Project leader: Isabella Dalle Donne
Oxidative stress-mediated effects of conventional and electronic cigarette smoke on pulmonary surfactant production and secretion in differentiated ATII alveolar cells
Project leader: Diletta Dolfini
Investigating the Role of NF-YA Isoforms in Epithelial Cancer Development
Project leader: Ignacio Ezquer
Uncovering Molecular Memory and signaling pathways from Parents to Offspring in plants: Epigenetic and Transcriptomic Switches in Seeds
Project leader: Alessandro Fantin
Exploiting zebrafish to uncover and tackle novel molecular mechanisms in Cornelia de Lange syndrome
Project leader: Paolo Gandellini
Functional analysis of dependency-associated non-coding RNAs to discover novel vulnerabilities of human cancer
Project leader: Veronica Gregis
Adapting reproductive meristems development in response to climate changes in Arabidopsis thaliana and Oryza sativa for yield improvement
Project leader: Martin Kater
Deciphering regulatory networks that control inflorescence architecture in rice: learning from diversity in the Oryza genus
Project leader: Paolo Landini
Molecular characterization of virulence factors in pathogenic Escherichia coli and identification of novel inhibitors
Project leader: Roberto Mantovani
Investigation of alternative splicing dysregulation in stomach and bladder Claudinlowtumors.
Project leader: Graziella Messina
Development of Multiple Strategies to Modulate Nfix in Cancer and Muscular Dystrophy
Project leader: Anna Moroni
Engineering of synthetic ion channels activated by remote stimuli
Project leader: Marco Nardini
The structure-function relationship of transcription factors implicated in diseases such as cancer and muscular dystrophy
Project leader: Marco Muzi Falconi
ZBED genes at the interface between inflammation and cancer
Project leader: Moira Paroni
Unveiling novel immunological and microbial targets in chronic inflammatory diseases
Project leader: Giorgio Perrella
Unveiling the genetic and epigenetic mechanisms related to environmental changes
Project leader: Paolo Pesaresi
PaleGreen CROPS to integrate sustainable production of food/feed and renewable energy through the agrivoltaic strategy
Project leader: Katia Petroni
Role of flavonoids in the prevention of inflammation and related molecular mechanisms
Project leader: Alessandra Polissi
Manipulating the cell envelope of Gram-negative bacteria as a strategy to develop next generation antibacterial drugs
Project leader: Stefano Ricagno
Structural and biophysical studies of light chains responsible for cardiac AL amyloidosis
Project leader: Sara Ricciardi
Modeling eIF2B variants to unravel the roles and mechanisms of translational control in the development of Vanishing White Matter Disease
Project leader: Luca Tadini
Molecular dissection of intracellular signaling pathways involved in chloroplast repair and degradation
Project leader: Federico Zambelli
Gene Regulation and Sequencing Analysis: Methodological Advances and Cloud-based Applications
Project leader: Graziella Cappelletti
Protein aggregation and neurodegeneration: mechanisms and modulators in central and peripheral nervous system
Project leader: Manuel Albanese - Stefano Biffo
Engineered Extracellular Vesicles for Personalized Therapy
Project leader: Mara Cucinotta - Lucia Colombo
Spatial transcriptomics to explore apomictic reproduction in plants
Project leader: Guido Papa - Marco Nardini
Studying the role of biomolecular condensates in viral infections for novel antiviral strategies based on targeted protein degradation
Research Project Summary XL CYCLE – A.Y. 2024-2025
Project leader: Annalisa Bucchi
Molecular basis of cardiac arrhythmias
Project leader: Carlo Camilloni
Molecular modelling of biomolecular self-assembly processes
Project leader: Graziella Cappelletti
Looking at the role of microtubule dysfunction and stress-related pathways in pathological alpha-synuclein aggregation
Project leader: Graziella Cappelletti
Flourish or perish: pro-regenerative epigenetic programme to sustain axonal sprouting of peripheral nerves - IRCCS Besta
Project leader: Elena Cattaneo
Evaluation of the identity, functionality, and immunogenicity of grafts of neurons or organoids derived from stem cells transplanted into an animal model of Huntington's Disease in association with neuroprotective treatments
Project leader: Elena Cattaneo
Development of a stem cell platform for studying cag somatic instability in huntington's disease through single-cell dna sequencing and transcriptional profiling of brain organoids and treated hd animal brains
Project leader: Matteo Chiara
Development and application of bioinformatics methods for the analysis, integration and interpretation of omics data
Project leader: Lucia Colombo
Studies of molecular and genetic mechanisms controlling the reproductive systems of plants to increase their productivity
Project leader: Lucio Conti
Multilevel integration of water deficit signals in the floral network
Project leader: Alex Costa - Maria Cristina Bonza
Deciphering Osmotic-Induced Long-Distance GLRs-Mediated Calcium Waves in Plants During the Recovery from Drought Stress
Project leader: Isabella Dalle Donne
Oxidative stress-mediated effects of conventional and electronic cigarette smoke on pulmonary surfactant production and secretion in differentiated ATII alveolar cells
Project leader: Diletta Dolfini
Investigation of alternative splicing dysregulation in stomach Claudin low tumors.
Project leader: Ignacio Ezquer
Genetic biodiversity study in crops to improve seed quality
Project leader: Alessandro Fantin
Defining novel molecular and cellular mechanisms that promote angiogenesis in neovascular diseases
Project leader: Fabio Fornara
The relationship between flowering and stem elongation in rice
Project leader: Paolo Gandellini
Functional analysis of dependency-associated non-coding RNAs to discover novel vulnerabilities of human cancer
Project leader: Veronica Gregis
Adapting reproductive meristems development in response to climate changes in Arabidopsis thaliana and Oryza sativa for yield improvement
Project leader: Martin Kater
Unraveling regulatory pathways that control inflorescence architecture in rice
Project leader: Roberto Mantovani
Molecular basis of DNA-binding and functional cooperativity of human Transcription Factors
Project leader: Eloise Mastrangelo - Alex Costa
Structural-based antiviral drug discovery and delivery system optimization
Project leader: Graziella Messina
Development of Multiple approaches to modulate Nfix in Cancer and Muscular Dystrophy
Project leader: Anna Moroni
Engineering of synthetic ion channels activated by remote stimuli
Project leader: Marco Nardini
Structural biology on transcription factors and on their interaction with DNA
Project leader: Giorgio Perrella
Unveiling the genetic and epigenetic mechanisms related to environmental changes
Project leader: Paolo Pesaresi
Searching for the best allelic variants responsible for the pale green leaf phenotype in barley
Project leader: Paolo Pesaresi
Identification of 8 aa cyclic and linear peptides to be used as sustainable alternative to conventional pesticides in agriculture..
Project leader: Katia Petroni
Role of flavonoids in the prevention of inflammation and related molecular mechanisms
Project leader: Katia Petroni
Unveiling the role of chlorogenic acid on anthocyanins bioactivity: a multi-species case study..
Project leader: Stefano Ricagno
Structural and biophysical characterization of the amyloidogenic proteins responsible for systemic amyloidoses
Project leader: Luca Tadini
Molecular dissection of intracellular signalling pathways involved in chloroplast repair and degradation in Arabidopsis thaliana and barley
Project leader: Thomas Vaccari
Growth potential of 29 T-dark genes associated with rare glial tumors
Project leader: Federico Zambelli
Development and implementation of cloud-oriented bioinformatic methods, tools and workflows
Project leader: Mario Milani
Biochemical and structural analysis of novel chimeric RNA binding proteins for gene therapy to suppress pathological inflammation in Multiple Sclerosis
Project leader: Giuseppina Caretti
Studying he methylase SMYD3 role in chromosome instability, in breast cancer
Project leader: Marco Muzi Falconi
Novel factors regulating genome stability at non-canonical chromosomal structures in normal and cancer cells
Project leader: Michele Mazzanti
Metformin administration combined with transcranial stimulation as a novel therapy against glioblastoma
Project leader: Alessandro Fantin
Novel roles for CXCR4 signaling in hematovascular development
Project leader: Stefano Biffo
Footprinting analysis of translational control of cells with tRNA mutations
Research Project Summary XXXIX CYCLE – A.Y. 2023-2024
Project leader: Andrea Francesco Barbuti
Mitochondrial dysfunction in atrial fibrillation pathogenesis
Project leader: Camilla Betti
Interactome studies on regulators of flower development in rice through advanced proteomics
Project leader: Stefano Biffo
Translational regulation of the tumor microenvironment
Project leader: Maria Cristina Bonza
Development of new strategies for plant phytopathogens protection
Project leader: Federica Briani
Elucidating key steps of Pseudomonas aeruginosa infection by lytic phages for phage therapy
Project leader: Matteo Brilli
Study of the recovery from Flavescence doreè in grapevine infected by Candidatus Phytoplasma vitis in vineyards excluded from re-infection by S.titanus
Project leader: Annalisa Bucchi
Study of the molecular mechanisms involved in cardiac rhythm disorders induced by inflammation
Project leader: Carlo Camilloni
Molecular modelling of biomolecular self-assembly processes
Project leader: Elena Cattaneo
A stem cell platform for the identification of modifiers of CAG repeat in the gene causing Huntington’s Disease
Project leader: Giuseppina Caretti
Epigenetic and metabolic targeting of skeletal muscle, during aging
Project leader: Matteo Chiara
Development and application of bioinformatics methods for the analysis, integration and interpretation of omics data
Project leader: Lucia Colombo
Adaptation and resilience to climate change of the reproductive mechanisms in higher plants
Project leader: Lucio Conti
Multilevel integration of water deficit signals in the floral network
Project leader: Alex Costa
Study of the molecular mechanisms involved in the propagation of systemic electrical and calcium signals in response to mechanical stimuli in plants
Project leader: Diletta Dolfini
Investigation of alternative splicing dysregulation in stomach Claudinlowtumors.
Project leader: Ignacio Ezquer
Biodiversity studies for adaptation to climate change tolerance in crops
Project leader: Alessandro Fantin
Defining the molecular and cellular mechanisms by which tissue macrophages promote angiogenesis in neovascular diseases
Project leader: Alessandro Fantin
Study of the molecular mechanisms controlling cardiovascular regenerative cell function in age-associated diseases
Project leader: Fabio Fornara
Role of mechanical forces during the floral transition of the rice shoot apical meristem
Project leader: Paolo Gandellini
Functional analysis of dependency-associated non-coding RNAs to discover novel vulnerabilities of human cancer
Project leader: Veronica Gregis
Adapting flowering time and floral meristem commitment in response to temperature increase in Arabidopsis thaliana and Brassica napus for yield improvement
Project leader: Martin Kater
Functional Analysis of Genes Controlling Inflorescence Architecture in Rice for Yield Improvement
Project leader: Paolo Landini
Molecular characterization of the role of single bacterial species from a multi-strain formulation marketed as probiotics on the virulence of clinical isolates from bacterial prostatitis
Project leader: Nicola Manfrini
Dissecting the role of the FAM46C/BCCIP complex in multiple myeloma
Project leader: Roberto Mantovani
Molecular bases of DNA-binding and functional cooperativity of human Transcription Factors
Project leader: Stefano Ricagno - Fabio Martelli
The potential of ncRNA as biomarkers of cardiovascular diseases
Project leader: Eloise Mastrangelo
A strategic approach to fight Flavivirus by targeting the replication complex
Project leader: Michele Mazzanti
Metformin administration combining with transcranial stimulation as a novel therapy against glioblastoma
Project leader: Graziella Messina
High-throughput screening to identify Nfix-modulators in Cancer and Muscular Dystrophies
Project leader: Mario Milani
New hybrid Proteins: novel tools to regulate neuroinflammation in Multiple Sclerosis
Project leader: Anna Moroni
Molecular characterization of early infantile epileptic encephalopathy (EIEE) related HCN1 mutations: advancing therapeutics and treatment
Project leader: Marco Muzi Falconi
Characterization of the relationship between G-quadruplex, 3D nuclear organization, and genome stability
Project leader: Marco Nardini
Cryo-EM structural biology on transcription factors and on their interaction with DNA
Project leader: Achille Pellicioli
Profiling transcription at DNA breaks to tackle genome instability
Project leader: Giorgio Perrella
Unravelling the function of chromatin remodellers in response to environmental stresses
Project leader: Paolo Pesaresi
Peptide-based fungicides for a sustainable agriculture
Project leader: Katia Petroni
Role of flavonoids in the prevention of inflammation and related molecular mechanisms
Project leader: Alessandra Polissi
Manipulating the outer membrane permeability of Gram-negative bacteria as a strategy to develop next generation antibacterial drugs
Project leader: Stefano Ricagno
Investigating the molecular role of N-glycosylation in the amyloid aggregation of kappa light chains found in AL-amyloidosis
Project leader: Stefano Ricagno
Biochemical and structural characterisation of toxic protein aggregates from cats affected by AA amyloidosis to design future treatments
Project leader: Elio Rossi
Identification of novel bacterial virulence factors and inflammation determinants associated with persistent lung infections in cystic fibrosis patients
Project leader: Thomas Vaccari
An in vivo model of intractable R257C-ACTG2 Visceral Myopathy to study pathogenesis and to identify new disease targets
Project leader: Thomas Vaccari
A Drosophila model of Type B Kufs/CLN13 disease to study pathogenesis and Cathepsin F function
Project leader: Roberto Mantovani
Towards diagnostic fingerprinting using new optical biosensor technologies
Project leader: Graziella Cappelletti
Looking at the role of microtubule dysfunction and RNA metabolism in pathological alpha-synuclein aggregation
Project leader: Luca Del Giacco
Modeling SMPX-linked hearing loss and distal myopathy in zebrafish
Project leader: Ignacio Ezquer
Uncovering seed biology traits governed by heterosis and their relation to environmental stress
Project leader: Graziella Cappelletti
Flourish or perish: pro-regenerative epigenetic programme to sustain axonal sprouting of peripheral nerves
Research Project Summary XXXVIII CYCLE – A.Y. 2022-2023
Project leader: Andrea Francesco Barbuti
Manipulation of caveolin expression levels to improve membrane fragility in caveolinopathies and muscular dystrophies to prevent myocytes lost and the onset of arrhythmias
Project leader: Beatrice Bodega
Defining LINE1-transcripts dynamics in tumor-infiltrating Tregs to unveil novel immunotherapeutic candidates
Project leader: Federica Briani
Biology of model phages for phage therapy against P. aeruginosa
Project leader: Annalisa Bucchi
Inflammation and cardiac rhythm disorders
Project leader: Carlo Camilloni
Molecular modelling of biomolecular self-assembly processes
Project leader: Graziella Cappelletti
Regulation of microtubules and RNA metabolism interaction in the neuron-astrocyte crosstalk during Parkinson’s Disease
Project leader: Graziella Cappelletti
Alpha-synuclein aggregation: modulators and impact on gut-brain axis.
Project leader: Giuseppina Caretti
Dissecting the role of the methylase SMYD3 in breast cancer stem cells.
Project leader: Elena Cattaneo
Human stem cell-based approaches for the study of transcriptional and chromatin abnormalities of Huntington’s disease neurons
Project leader: Elena Cattaneo
Identifying the cell-specific neurodevelopmental component of Huntington disease in the cortex using combined single-cell RNA and ATAC sequencing
Project leader: Elena Cattaneo
Identifying the cell-specific neurodevelopmental component of Huntington disease in the striatum using combined single-cell RNA and ATAC sequencing
Project leader: Stefano Biffo
In silico approaches to study T cell trajectories
Project leader: Alex Costa
New state-of-the-art imaging tools to study how crops adapt to environmental changes
Project leader: Stefano Biffo
Tumor-T cell organoid interaction
Project leader: Matteo Chiara
Bioinformatics tools for variant prioritization in precision medicine
Project leader: Lucia Colombo
Toward understanding the molecular and genetic mechanisms controlling female germline differentiation
Project leader: Luca Del Giacco
Modeling SMPX-linked hearing loss and distal myopathy in zebrafish
Project leader: Diletta Dolfini
Investigation of alternative splicing dysregulation in tumors
Project leader: Ignacio Ezquer
Uncovering molecular regulators as well as signaling cascades involved in intercompartmental communication that control seed development
Project leader: Camilla Betti
Rice Glycogen Synthase Kinases: untangling biological roles in flower development and stress responses
Project leader: Alessandro Fantin
Defining the molecular and cellular mechanisms by which tissue macrophages promote angiogenesis in neovascular diseases
Project leader: Fabio Fornara
Analysis of the relationship between internode elongation and gibberellin signalling in rice
Project leader: Paolo Gandellini
Functional dissection of the canonical and non-canonical interplay between noncoding RNAs and NFY transcription factor in human cancer
Project leader: Giuliana Giannuzzi
Genetic diversity, evolution and functional impact of structurally complex loci of the human genome
Project leader: Martin Kater
Functional Analysis of Genes Controlling Inflorescence Architecture in Rice
Project leader: Roberto Mantovani
High-throughput screening to identify Nfix-inhibiting drugs in Cancer and Muscular Dystrophies
Project leader: Paolo Landini
Cyclic dinucleotides presiding to gene expression and acting as interkingdom signals in adherent invasive Escherichia coli (AIEC) associated with Crohn's disease
Project leader: Graziella Messina
Development of a liposome-based and nutrigenomic approach to silence the transcription factor Nfix in muscular dystrophy
Project leader: Anna Moroni
Cryo-EM Structural studies of the HCN2 channel for future therapeutical treatments of chronic pain
Project leader: Marco Nardini
Structural analysis and development of inhibitors of the enzyme D-Asp oxidase through biochemical, biophysical and computational approaches
Project leader: Moira Paroni
Functional and molecular characterization of the interaction between P. aeruginosa and lunginfiltrating Th1/17 cells in Cystic Fibrosis.
Project leader: Giorgio Perrella
Unravelling the role of chromatin remodellers in response to environmental stimuli
Project leader: Katia Petroni
Protective role of anthocyanins in cell model systems and dietary treatments in mice
Project leader: Stefano Ricagno
The lysosomal amyloid aggregation of β2-microglobulin promotes Multiple myeloma progression: a molecular focus on this pro-cancer mechanism
Project leader: Thomas Vaccari
Dissection of smooth muscle functionality in clinically-relevant in vivo models of visceral myopathy
Project leader: Federico Zambelli
Development and implementation of cloud-oriented bioinformatic tools and workflows
Project leader: Eloise Mastrangelo
Large-scale druggability assessment of target libraries with artificial intelligence-based structure-sequence combined features
Project leader: Marco Muzi Falconi
Studying the molecular mechanisms responsible for the maintenance of genome integrity and their connections to human pathologies
Project leader: Achille Pellicioli
Profiling transcription at DNA breaks to tackle genome instability
Project leader: Nerina Gnesutta
Molecular bases of DNA-binding and functional cooperativity of human Transcription Factors
Project leader: Sara Ricciardi
Application of CRISPR-based Prime Editing as a modeling tool to unveil the mechanisms of Vanishing White Matter disease
Project leader: Michele Mazzanti
Study of the antiproliferative effect of metformin combined to transcranial stimulation in glioblastoma cellular and animal models
Project leader: Stefano Biffo
Translational regulation of gene expression
Project leader: Anna Moroni
Technology transfer from lab to market: the case of TICK
Project leader: Alessandra Polissi
LPS export through peptidoglycan as novel target for OM destabilization
Project leader: Alessandra Polissi
A new biological reporter to signal disruption of the LPS and consequent OM destabilization
Research Project Summary XXXVII CYCLE – A.Y. 2021-2022
Project leader: Andrea Francesco Barbuti
Cav-1 expression for limiting membrane stress and electrical alterations of cardiomyocytes of patients with caveolinopathies and muscular dystrophies
Project leader: Stefano Biffo
Single cell analysis of the translatome of tumor infiltrating lymphocytes
Project leader: Beatrice Bodega
Dissecting non-coding genome function to identify novel epigenetic regulators in T lymphocytes maturation
Project leader: Federica Briani
Molecular characterization of disease-linked human polynucleotide phosphorylase (hPNPase) variants
Project leader: Annalisa Bucchi
Inflammation and Sinus Node Disease
Project leader: Carlo Camilloni
Integrative modelling of molecular recognition processes by molecular dynamics simulations
Project leader: Graziella Cappelletti
Regulation of microtubules and RNA metabolism interaction in the neuron-astrocyte crosstalk during Parkinson’s Disease
Project leader: Elena Cattaneo
Study of Huntingtin function and dysfunction in neuronal cells
Project leader: Alex Costa
Elucidation of molecular mechanisms involved in systemic signal propagation upon wounding and herbivory attack in plants
Project leader: Diletta Dolfini
Role of transcription factor NF-YA in tissue specification in mouse embryo development
Project leader: Alessandro Fantin
Defining the molecular and cellular mechanisms by which tissue macrophages promote angiogenesis in neovascular diseases
Project leader: Fabio Fornara
Defining the function of rice florigenic proteins during the reproductive transition and inflorescence development
Project leader: Paolo Gandellini
Functional dissection of noncoding RNAs regulating NFY transcription factor in human cancer
Project leader: Michele Mazzanti
Study of the antiproliferative effect of metformin combined to transcranial stimulation in glioblastoma cellular and animal models
Project leader: Louise Gourlay
Structure and functional studies of self-assembling multi-enzyme nanoparticles for continuous redox biocatalysis
Project leader: Martin Kater
Modifying phyllotaxis in Brassica seed crop species for yield improvement
Project leader: Graziella Messina
Development of genetic and pharmacological approaches to cure Muscular Dystrophies
Project leader: Anna Moroni
Mechanisms of enzymatic control of HCN4 (funny current) channels in cardiac pacemaker myocytes and rhythm modulation
Project leader: Andrea Saponaro
cryo-EM Structural studies of the HCN2 channel for future terapeutical treatments of chronic pain
Project leader: Moira Paroni
Counteracting inflammation triggered by P. aeruginosa-activated lung-infiltrating Th1/17 cells: a novel approach for precision medicine in CF
Project leader: Marco Muzi Falconi
G quadruplex as sources of genome instability: identification and characterization of novel mechanisms and factors in cancer cells
Project leader: Marco Nardini
Integrated structural biology on transcription factors and their interaction with DNA
Project leader: Achille Pellicioli
Studying the functional role of PARP1 in DNA double strand break processing to target cancer cells
Project leader: Paolo Pesaresi
BarPLUS: improving photosynthesis in barley to increase the production of biomass that can be converted into biofuel
Project leader: Alessandra Polissi
Breaking Gram-negative bacteria outer membrane permeability barrier as a strategy to develop of next generation antibacterial drugs
Project leader: Stefano Ricagno
β2-microglobulin amyloid aggregation promotes Multiple myeloma progression: towards the understanding of the molecular bases
Project leader: Paolo Landini
Identification of novel bacterial virulence factors and inflammation determinants associated with persistent lung infections in cystic fibrosis patients
Project leader: Thomas Vaccari
New regulators of autophagy and endo-lysosomal trafficking in cell and in vivo models of disease
Project leader: Federico Zambelli
Development and implementation of cloud-oriented bioinformatic tools and workflows
Project leader: Paolo Pesaresi
New antimicrobial peptides for a sustainable agriculture
Project leader: Martin Kater
Miglioramento della resa del riso: più cibo con meno superficie coltivata
Project leader: Martin Kater
Approcci genomici allo studio della conservazione della biodiversità di specie di piante medicinali
Project leader: Lucia Colombo
Food security: Innovative plant reproductive strategy in a chancing environmental condition.
Project leader: Lucia Colombo
Secure plant fertility in a changing climate
Research Project Summary XXXVI CYCLE – A.Y. 2020-2021
Project leader: Alessandro Aliverti
From protein structure to novel therapeutics against rare genetic diseases
Project leader: Andrea Francesco Barbuti
Study of the functional and molecular mechanisms of familial cardiac pathologies using human and murine pluripotent stem cells
Project leader:
Transposon Landscape Variation and its Influence on Phenotype Diversity in Plants
Project leader: Maria Cristina Bonza
Characterisation of MIZ1-ECA1 interaction to shed light on the mechanisms underlying long-distance Ca2+ signalling in plants
Project leader: Matteo Brilli
Integrating pathogen genomes and health big data for challenging health-associated infections
Project leader: Annalisa Bucchi
Study of the molecular mechanisms underlying the genesis and control of the cardiac rhythm in physiological and pathological conditions: FGF21 and sinoatrial node activity
Project leader: Lucia Colombo
Genetic network controlling reproductive development in plants
Project leader: Carlo Camilloni
Computational design of enhanced class I MHC antigens
Project leader: Graziella Cappelletti
Regulation of microtubules and RNA metabolism interaction in the neuron-astrocyte crosstalk during Parkinson’s Disease
Project leader: Elena Cattaneo
Stem Cell-based approaches for understanding Huntington’s Disease
Project leader: Alex Costa
Harnessing the new emerging imaging technologies to uncover the role of Ca2+ signaling in plant nutrient homeostasis
Project leader: Luca Del Giacco
A multi-tiered approach to unravel the molecular bases of SOD1-mediated ALS Pathogenesis
Project leader: Diletta Dolfini
Bioinformatic Identification of key transcription factors in epithelial tumors
Project leader: Ignacio Ezquer
Deciphering new molecular regulators towards next generation hybrids in Agriculture
Project leader: Alessandro Fantin
Defining the molecular and cellular mechanisms by which tissue macrophages promote angiogenesis in neovascular diseases
Project leader: Fabio Fornara
Molecular control of plant reproductive development in response to day length
Project leader: Federico Lazzaro
Identification and characterisation of new factors involved in maintaining genome stability
Project leader: Nerina Gnesutta
Stress-response signal integration by Transcription Factors interactions
Project leader: Paolo Landini
Pseudomonas aeruginosa determinants for chronic inflammation in cystic fibrosis
Project leader: Martin Kater
Functional Analysis of Genes Controlling Inflorescence Architecture in Arabidopsis and Rice
Project leader: Roberto Mantovani
Role of NF-YA isoforms in breast cancer
Project leader: Michele Mazzanti
Study of the antiproliferative effect of metformin combined to transcranial stimulation in glioblastoma cellular and animal models
Project leader: Graziella Messina
Development of genetic and pharmacological approaches to cure Muscular Dystrophies
Project leader: Anna Moroni
Molecular characterization of early infantile epileptic encephalopathy (EIEE) related HCN1 mutations: advancing therapeutics and treatment
Project leader: Marco Muzi Falconi
The response to DNA damage in non-proliferating cells: mechanisms and pathologies
Project leader: Marco Nardini
Structural architecture of the “pioneer” transcription factor NF-Y and its companions on DNA
Project leader: Alessandra Polissi
Envelope biogenesis in Gram-negative bacteria as molecular target for the development of next generation antibacterial drugs
Project leader: Achille Pellicioli
Insights into the role of DNA break processing factors in maintaining genome stability to target cancer cells
Project leader: Paolo Pesaresi
BarPLUS: improving photosynthesis in barley to increase the production of biomass that can be converted into biofuel
Project leader: Stefano Ricagno
Structural bases of amyloid aggregation in Light Chain Amyloidosis
Project leader: Andrea Saponaro
Insight into the Walker-Warburg Syndrome: structure-function of the membrane protein POMT1/2 complex
Project leader:
Mechanisms of anthocyanin cardioprotection
Project leader: Federico Zambelli
Development and implementation of cloud-oriented bioinformatic tools and workflows
Project leader: Andrea Francesco Barbuti
Circular-RNA regulation in ischemic heart failure
Research Project Summary XXXV CYCLE – A.Y. 2019-2020
Project leader: Alessandro Aliverti
From protein structure to novel therapeutics against rare genetic diseases
Project leader: Stefano Biffo
Immunoregulation in the tumor microenvironment
Project leader:
Characterization of the Genetic Basis of the Pawpaw (Asimina triloba) Domestication
Project leader: Maria Cristina Bonza
Characterisation of MIZ1-ECA1 interaction to shed light on the mechanisms underlying long-distance Ca2+ signalling in plants
Project leader: Federica Briani
Exploiting Escherichia coli to understand the molecular defects of disease-linked polynucleotide phosphorylase (hPNPase) variants
Project leader: Matteo Brilli
Integrating pathogen genomes and health big data for challenging health-associated infections
Project leader: Carlo Camilloni
Molecular modelling of biomolecular self-assembly processes
Project leader: Graziella Cappelletti
Microtubule dysfunction and neurodegeneration: dissecting the interplay of α-synuclein with tubulin in models of Parkinson's disease
Project leader:
In vivo modelling of liver cancer to resolve the chromatin dependencies of intestinal dysbiosis
Project leader: Elena Cattaneo
Huntington's Disease: biological and molecular aspects in neurons and glia derived from pluripotent stem cells
Project leader: Lucio Conti
Integration of drought and phyto-hormonal signals at the shoot apical meristem of plants
Project leader: Alex Costa
Harnessing the new emerging imaging technologies to uncover the role of Ca2+ signaling in plant nutrient homeostasis
Project leader: Luca Del Giacco
Smpx-deficient zebrafish: a tool for studying human hearing loss
Project leader: Diletta Dolfini
Study of NF-Y expression across TCGA cancer datasets
Project leader: Alessandro Fantin
Defining the molecular and cellular mechanisms by which tissue macrophages promote angiogenesis in neovascular diseases
Project leader: Fabio Fornara
Uncoupling flowering from internode elongation during the floral transition of rice
Project leader: Paolo Gandellini
Dissecting The Role Of Nfy “Mirnome” In Human Cancer
Project leader: Martin Kater
Functional Analysis of Genes Controlling Inflorescence Architecture in Arabidopsis and Rice
Project leader: Paolo Landini
Role of c-di-GMP and other nucleotide-derived signal molecules in Crohn’s disease-associated host-bacteria interaction
Project leader: Roberto Mantovani
Transcription factor NF-Y partnerships in the regulation of ER-stress response genes
Project leader: Michele Mazzanti
Study of the antiproliferative effect of metformin combined to transcranial stimulation in glioblastoma cellular and animal models
Project leader: Graziella Messina
Development of genetic and pharmacological approaches to cure Muscular Dystrophies
Project leader: Anna Moroni
Engineering of synthetic protein tools for optogenetics
Project leader: Marco Nardini
Biophysical and structural (NMR and crystallography) characterization of the transcription factor Nf1x involved in muscular dystrophy
Project leader: Moira Paroni
Unveiling the AIEC-antigens and gut-microbiota species involved in modulation of pathogenic Th1/17 cells differentiation and activation in Crohn’s disease
Project leader: Giulio Pavesi
Accumulation of replication/repair intermediates as a cause for genomic instability: integrated in vivo and in silico studies
Project leader: Paolo Pesaresi
SOUP: Signaling the Organelle Unfolded Protein response
Project leader: Alessandra Polissi
Envelope biogenesis in Gram-negative bacteria as molecular target for the development of next generation antibacterial drugs
Project leader: Achille Pellicioli
Exploiting the CRISPR-Cas9 technology to study the double strand DNA break repair and genome stability
Project leader: Stefano Ricagno
Dissecting the molecular bases of Human Light Chains “soluble toxicity”
Project leader: Thomas Vaccari
USP36, a novel repressor of Notch signaling in human cells
Project leader: Federico Zambelli
Development and implementation of cloud-oriented bioinformatic tools and workflows
Project leader: Lucia Colombo
New insights in germ line development in plants
Project leader: Graziella Cappelletti
Modulatin of lysosome function and α-sinuclein accumulation by Leucine-Rich Repeat Kinase 2 (LRRK2): towards a pathway for Parkinson’s disease
Research Project Summary XXXIV CYCLE – A.Y. 2018-2019
Project leader: Alessandro Aliverti
From protein structure to novel therapeutics against rare genetic diseases
Project leader: Monica Beltrame
Transgenic lines, morpholinos and mutants to study regulatory networks in zebrafish
Project leader: Stefano Biffo
Functional study on Fam46c tumor suppressor in multiple myeloma
Project leader: Stefano Biffo
eIF6 Gene dosage effects on the development of Drosophila melanogaster
Project leader: Federica Briani
New therapeutic strategies against Gram-negative bacteria: identification and characterization of moleculartargets for novel antibacterial drugs
Project leader: Carlo Camilloni
Integrative modelling of molecular recognition processes by means of computer simulations
Project leader: Graziella Cappelletti
Microtubule dysfunction and neurodegeneration: dissecting the interplay of alpha-synuclein with tubulin in models of Parkinson's disease
Project leader: Elena Cattaneo
Huntington’s Disease: biological and molecular aspects in neurons and glia derived from pluripotent stem cells
Project leader: Lucia Colombo
Evolution of molecular networks controlling the seed coat differentiation
Project leader: Lucio Conti
Integration of drought and phyto-hormonal signals in the shoot apical meristem of plants
Project leader: Alex Costa
Study of the physiological role played by the aminoacid-binding domain of Arabidopsis Glutamate like receptor-channels
Project leader: Ignacio Ezquer
Molecular, metabolic and structural bases of seed formation
Project leader: Fabio Fornara
Genetic and molecular control of flowering in rice
Project leader: Luisa Guerrini
Analysis of the molecular mechanisms at the basis of thalidomide-induced limb defects in zebra fish embryos
Project leader: Martin Kater
Functional Analysis of Genes Controlling Inflorescence Architecture
Project leader: Paolo Landini
Role of c-di-GMP and other nucleotide-derived signal molecules in Crohn’s disease-associated host-bacteria interaction
Project leader: Federico Lazzaro
Vid22 as a new player to maintain genome stability
Project leader: Roberto Mantovani
Role of NF-YA in development of epithelial cancers
Project leader: Federica Marini
Insights into the role of DNA break processing factors in maintaining genome stability to target cancer cells
Project leader: Michele Mazzanti
Reciprocal interactions between glioblastoma stem cells and cancer-associated microglia during brain tumor development
Project leader: Marta A. Miranda Mendes
Molecular control of sporogenesis in plants
Project leader: Graziella Messina
Development of genetic and pharmacological approaches to cure Muscular Dystrophies
Project leader: Anna Moroni
Engineering of synthetic protein tools for optogenetics
Project leader: Marco Muzi Falconi
The response to DNA damage in nonproliferating cells: mechanisms and pathologies
Project leader: Marco Nardini
Biophysical and structural (NMR and crystallography) characterization of the transcription factor Nf1x involved in muscular dystrophy
Project leader: Achille Pellicioli
Exploiting the CRISPR-Cas9 technology to study the double strand DNA break repair and genome stability.
Project leader: Katia Petroni
Mechanism of anthocyanin cardioprotection against doxorubicin-mediated autophagy dysregulation
Project leader: Paolo Pesaresi
Organelle-Nucleus Communication Elements: Discovering the molecular details of the retrograde signaling pathway
Project leader: Alessandra Polissi
Envelope biogenesis in Gram-negative bacteria as molecular target for the development of next generation antibacterial drugs
Project leader: Stefano Ricagno
Light chain amyloidosis: towards the understanding of the molecular bases of cardiotoxic amyloid aggregation
Project leader: Andrea Saponaro
Molecular insights into ion channel gating mechanisms
Project leader: Thomas Vaccari
Systematic genetic and pharmacologic modulation of Notch signaling and tumorigenesis in Drosophila
Project leader: Maria Antonietta Vanoni
Dissecting the mechanism of action and regulation of human MICAL1, the multidomain flavoenzyme participating in actin cytoskeleton dynamics
Project leader: Chiara Zuccato
Molecular and cellular strategies to counteract defects in Huntington's disease models
Project leader: Diletta Dolfini
Study of NF-Y expression across TCGA cancer datasets
Project leader: Thomas Vaccari
Characterization of the mechanism of Notch signaling modulation by trafficking in human cells
Research Project Summary XXXIII CYCLE – A.Y. 2017-2018
Project leader: Monica Beltrame
Transgenic lines, morpholinos and mutants to study regulatory networks in zebrafish
Project leader: Giovanni Bertoni
Molecular mechanisms of host-pathogen interaction: role of small RNAs in the regulation of virulence in the opportunistic pathogen Pseudomonas aeruginosa
Project leader: Stefano Biffo
Functional study on Fam46c tumor suppressor in multiple myeloma
Project leader: Federica Briani
Regulation of the Escherichia coli lpxT gene: interplay between translation and mRNA stability control
Project leader:
Structure based epitope design for the development of immunodiagnostics targeting emerging infections in Lombardy
Project leader: Carlo Camilloni
Integrative modelling of molecular recognition processes by means of computer simulations
Project leader: Graziella Cappelletti
Dissecting the role of α–synuclein at the synapse in health and disease: the impact on microtubule dynamics
Project leader: Elena Cattaneo
Development of strategies to rescue synaptic and behavioral defects in Huntington's disease mice
Project leader: Elena Cattaneo
Optimization of striatal differentiation protocols using human pluripotent stem cells
Project leader: Elena Cattaneo
Transcriptional profiling the developing human striatum at whole population and single cell level
Project leader: Lucia Colombo
Genetic and Epigenetic regulation of ovule development
Project leader: Lucio Conti
Integration of drought and phyto-hormonal signals in the shoot apical meristem of plants
Project leader: Alex Costa
High resolution molecular imaging in living organisms: development of new biological tools and their use with confocal and multiphoton microscopy
Project leader: Fabio Fornara
Genome-wide DNA binding patterns of a flowering regulator of rice
Project leader: Nerina Gnesutta
NF-Y partners in the regulation of CCAAT promoters
Project leader: Luisa Guerrini
Analysis of the molecular mechanisms at the basis of thalidomide-induced limb defects in zebra fish embryos
Project leader: Martin Kater
Functional analysis of genes controlling inflorescence architecture
Project leader: Paolo Landini
Role of c-di-GMP and other nucleotide-derived signal molecules in Crohn’s disease-associated host-bacteria interaction
Project leader: Federico Lazzaro
Role of Translesion Synthesis (TLS) polymerases in rNMPs incorporation during DNA replication
Project leader: Roberto Mantovani
Role of NF-Y in muscle
Project leader: Marta A. Miranda Mendes
Molecular control of sporogenesis in plants
Project leader: Graziella Messina
Study on a molecular approach to improve the cell therapy for Muscular Dystrophy: unravelling differences between Satellite Cells and Mesoangioblasts to promote Satellite Cell migration through the vessel wall
Project leader: Mario Milani
Structural basis for cone dystrophies: toward the design of new therapeutic molecules
Project leader: Anna Moroni
Ion channel engineering for magnetogenetics
Project leader: Marco Muzi Falconi
Analyses of the molecular mechanisms responsible for repairing cytotoxic lesions induced by UV light
Project leader: Marco Nardini
Structural analysis of transcription factor/DNA complexes
Project leader: Giulio Pavesi
Genome-wide analysis of long-distance chromatin regulatory interactions
Project leader: Achille Pellicioli
Insights into the role of DNA break processing factors in maintaining genome stability to target cancer cells
Project leader: Katia Petroni
Molecular mechanism of dietary anthocyanins in prevention of doxorubicin-induced cardiotoxicity
Project leader: Paolo Pesaresi
BarPLUS: modifying photosynthesis to maximize barley biomass and yield for biofuel production
Project leader: Stefano Ricagno
Structural and biophysical studies on Neuroserpin neurotoxic polymers
Project leader: Thomas Vaccari
Systematic genetic and pharmacologic modulation of Notch signaling and tumorigenesis in Drosophila
Project leader: Marta Valenza
Huntington's Disease: biological and molecular aspects in neurons and glia derived from pluripotent stem cells
Project leader: Chiara Zuccato
Molecular cellular strategies to counteract defects in Huntington's disease models
Research Project Summary XXXII CYCLE – A.Y. 2016-2017
Project leader: Alessandro Aliverti
Targeting mitochondrial proteins involved in apoptosis and cellular metabolism regulation to counteract cancer progression
Project leader:
Anti-viral drug discovery strategies: structure-based development of inhibitors of enzymes involved in flaviviral replication
Project leader: Graziella Cappelletti
Protein-protein interaction in regulating microtubule dynamics: the role in neurodegeneration
Project leader: Elena Cattaneo
Stem cells for studies of Huntington's Disease
Project leader: Lucia Colombo
Environmental and genetic control of seed number
Project leader: Fabio Fornara
Rice adaptation to higher latitudes by modification of photoperiod sensitivity
Project leader: Nerina Gnesutta
NF-Y partners in the regulation of CCAAT promoters
Project leader: Veronica Gregis
Study of transcription factors involved in reproductive development in the model species Arabidospis thaliana
Project leader: Luisa Guerrini
Analysis of the molecular mechanisms at the basis of thalidomide-induced limb defects in zebra fish embryos
Project leader: Martin Kater
Rice Yield Increase by Altering Inflorescence Architecture
Project leader: Paolo Landini
Inhibition of bacterial antigen production as a strategy to counteract chronic inflammation in Crohn's disease
Project leader: Federico Lazzaro
Role of Translesion Synthesis (TLS) polymerases in rNMPs incorporation during DNA replication
Project leader: Roberto Mantovani
Role of NF-YA isoforms in Embryonic Stem cells
Project leader: Federica Marini
Role of the SLX4 network in genome integrity maintenance and cancer prevention
Project leader: Graziella Messina
Study on a molecular approach to improve the cell therapy for Muscular Dystrophy: unravelling differences between Satellite Cells and Mesoangioblasts to promote Satellite Cell migration through the vessel wall
Project leader: Anna Moroni
Engineering of synthetic ion channels activated by remote stimuli
Project leader: Anna Moroni
Chimeric ion channel as a tool to study conformational changes during pore gating
Project leader: Marco Muzi Falconi
From Molecular Mechanisms to Human Pathologies Linked to Genome Instability
Project leader: Marco Muzi Falconi
Development of novel technologies for studying the interactions between physiological/pathological nucleic acid structures and proteins
Project leader: Marco Nardini
Structural analysis of transcription factor/DNA complexes
Project leader: Achille Pellicioli
Polo kinases and genome instability: implication for cancer development and treatment Background
Project leader: Paolo Pesaresi
BarPLUS: modifying photosynthesis to maximize barley biomass and yield for biofuel production
Project leader: Katia Petroni
Role of anthocyanin-enriched diet on cardioprotection
Project leader: Alessandra Polissi
Envelope biogenesis in Gram-negative bacteria as molecular target for the development of next generation antibacterial drugs
Project leader: Stefano Ricagno
Structural characterization of the receptor EP1 from Arabidopsis thaliana
Project leader:
Role of plant hormone signalling in the natural variation of flowering and adaptation in response to water scarcity through QTL and eQTL dissection
Project leader: Chiara Zuccato
Huntington's Disease: biological aspects and pathogenesis
Research Project Summary XXXI CYCLE – A.Y. 2015-2016
Project leader: Lucia Colombo
Titolo del progetto
Project leader: Giovanni Bertoni
Molecular mechanisms of host-pathogen interaction: role of small RNAs in the regulation of virulence in the opportunistic pathogen Pseudomonas aeruginosa
Project leader: Stefano Biffo
Effects of mutant eukaryotic Initiation Factor 6 (eIF6Ser235Ala) on tumor progression
Project leader: Federica Briani
Development of new tools to fight bacterial infections
Project leader:
Acid sensing ion channels (ASICs): validated targets in multiple sclerosis
Project leader: Graziella Cappelletti
Molecular architecture of neuronal microtubules in health and disease: unravelling the contribution of parkin
Project leader: Elena Cattaneo
Stem cells for studies of Huntington's Disease
Project leader: Lucia Colombo
Epigenetic regulation of ovule development in changing environmental conditions
Project leader: Alex Costa
Functional characterization of the Arabidopsis thaliana GLR3.7 (glutamate-like receptors)
Project leader: Fabio Fornara
Heading North! The genetics of rice adaptation to high latitudes
Project leader: Luisa Guerrini
Analysis of the molecular mechanisms at the basis of thalidomide-induced limb defects in zebra fish embryos
Project leader: Martin Kater
Rice Yield Increase by Altering Inflorescence Architecture
Project leader: Federico Lazzaro
Role of the ubiquitin ligases Dma1 and Dma2 in the DNA Double Strand Breaks response
Project leader: Roberto Mantovani
NF-YA in Embryonic Stem cells
Project leader: Graziella Messina
Vessel associated progenitor cells in the cell based Therapy of the Cystic Fibrosis lung disease
Project leader: Anna Moroni
The modulation of HCN channels by intracellular molecules
Project leader: Anna Moroni
Learning by building: constructing a voltage-gated ion channel from individual modular components
Project leader: Marco Muzi Falconi
Characterization of the role of EXO1 and Y-family DNA polymerases in processing UV-damaged DNA
Project leader: Marco Nardini
Structural analysis of transcription factor/DNA complexes
Project leader: Achille Pellicioli
Unravelling the role of the SLX4 pathway in preserving genome integrity and preventing cancer development
Project leader: Paolo Pesaresi
Organelle-Nucleus Communication Elements: An approach to uncover the molecular details of the retrograde signaling pathway
Project leader: Katia Petroni
Role of anthocyanin-enriched diet on cardioprotection
Project leader: Stefano Ricagno
Towards the understanding of light chains cardiotoxicity, a biochemical and structural investigation
Project leader:
Adaptomics. Exploring the natural variation of complex traits in plants through QTL and eQTL dissection
Project leader: Chiara Zuccato
Huntington's Disease: biological aspects and pathogenesis