Luca Broggini
Email: luca.broggini@unimi.it
Cicle: XXXIII A.Y. 2017 - 2018
Supervisor: Stefano Ricagno
Title: Structural and biophysical studies on Neuroserpin neurotoxic polymers … read more

External links: Scopus Linkedin


Curriculum vitae: >>>


Conferences / Workshops:

Starting Date	Ending Date	Title	Place
27/01/2019	30/01/2019	NMR: a tool for biology	Insitut Pasteur, Paris, France
08/07/2019	13/07/2019	EMBO course: Integrative structural and cellular biology	Insitut Pasteur, Paris, France
14/10/2019	20/10/2019	EMBO course: Structural and biophysical methods for biological macromolecules in solution	Santiago de Chile, Chile

Publications:

 Investigating the Molecular Basis of the Aggregation Propensity of the Pathological D76N Mutant of Beta-2 Microglobulin: Role of the Denatured State
Visconti L., Malagrinò F., Broggini L., De Luca CMG., Moda F., Gianni S., Ricagno S., Toto A.
International Journal of Molecular Sciences

 Biochemical and biophysical comparison of human and mouse beta‐2 microglobulin reveals the molecular determinants of low amyloid propensity
Achour A., Broggini L., Han X., Sun R., Santambrogio C., Buratto J., Visentin C., Barbiroli A., De Luca C., Sormanni P., Moda F., De Simone A., Sandalova T., Grandori R., Camilloni C., Ricagno S.
The FEBS journal

 Glycosylation Tunes Neuroserpin Physiological and Pathological Properties
Visentin C., Broggini L., Sala B., Russo R., Barbiroli A., Santambrogio C., Nonnis S., Dubnovitsky A., Bolognesi M., Miranda E., Achour A., Ricagno S.
International Journal of Molecular Sciences

 Embelin as Lead Compound for New Neuroserpin Polymerization Inhibitors
Visentin C., Musso L., Broggini L., Bonato F., Russo R., Moriconi C., Bolognesi M., Miranda E., Dellavalle S., Passarella D., Ricagno S.
Life

Native neuroserpin mechanism of action

Native to cleaved state transition. Upon cleavage of the scissile bond, the reactive center loop is inserted within β-strand A forming a stable and inactive cleaved state.