Roberta Castelli
Email: roberta.castelli@unimi.it
Cicle: XXXVIII A.Y. 2022 - 2023
Supervisor: Anna Moroni
Title: Novel therapeutic approaches emerging from HCN channels structural and functional studies … read more

External links: GoogleScholar Scopus ORCID

PhD Seminars:

Date	Title	Speakers
20/02/2023	How do you feel? The Molecules that Sense Touch	Ardem Patapoutian
21/02/2023	A nanobody toolkit for the regulation of K2P channel function	Stephen J. Tucker
21/02/2023	Potassium channel openers targeting different sites of the channel	Fredrik Elinder
14/03/2023	The CFTR corrector C17 is effective in sarcoglycanopathies: proof of concept and ADME studies	Dorianna Sandonà
15/03/2023	A functional genomics framework to investigate the molecular bases of rare genetic diseases	Davide Cacchiarelli
21/04/2023	Computational modeling: a quantitative tool to investigate cardiac cellular electrophysiology	Stefano Severi
06/09/2023	Unconventional approaches to single cell recordings	Claudio Grosman
07/09/2023	How can snails help us understand memory formation	Jelena Baranovic
08/09/2023	CaMKII activity spreads by inter-holoenzyme phosphorylation	Iva Lučić
05/10/2023	Molecule, cell, organism: multi-level analysis of a sick ion channel	Bina Santoro
05/10/2023	A small-molecule precision medicine for HCN1 DEE	Christopher Reid
13/03/2024	Rethinking the role of the piriform cortex in odor forming	Kevin Franks
11/04/2024	Minding what matters: philosophy in neuroscience	Paul Linton, John Morrison, Nedah Nemati
12/04/2024	Organization and control of hippocampal circuits	Ivan Soltesz
02/07/2024	The dynamic structure of cognition	André Fenton
07/08/2024	Optogenetic mimicry to improve the circuit model of drug addiction	Christian Lüscher
13/08/2024	Mechanisms of hippocampal learning and memory	Jeffrey Magee
09/09/2024	Cell adhesion molecules control distinct spatiotemporal aspects of neuronal remodeling	Oren Schuldiner
10/09/2024	From genes to function: Leveraging genomic insights from the past decade toward understanding the etiology of severe psychiatric disorders	Tarjinder (TJ) Singh
14/10/2024	The electrophisiological signatures of naturalistic memory encoding	Marta Silva
23/10/2024	Evolution of telencephalic interneuron diversity across vertebrates	Giacomo Gattoni
06/11/2024	Dimensionality and dynamics of decision-making in simultaneous recordings from the hippocampus, prefrontal, and premotor cortex of virtually navigating macaques	Roberto Gulli
13/11/2024	Imaging genome organization and transcriptional regulation in live olfactory neurons	Joan Pulupa
10/12/2024	Electrical synapses act as a magnitude filter to modulate sensory information processing and behavioral choices in C. elegans	Daniel Colón-Ramos
15/01/2025	How does the brain read? An investigation of top-down control during visual word recognition	Vassiki Chauhani
21/01/2025	Applications of human PSCs in modeling and treating neural disease	Lorenz Studer
05/02/2025	A novel theory of information demand in the framework of probabilistic reasoning	Matthew Jiwa
15/02/2025	How to discover sequence to function relationships across multi-pass membrane proteome	Willow Coyote-Maestas
14/03/2025	Proton selective conductance and gating of lysosomal cation channel TMEM175	Oliver Rauh

PhD Courses:

Starting Date	Ending Date	Title	Place
09/01/2023	31/01/2023	Biostatistics for Molecular and Cellular Biology	Università degli studi di Milano
13/02/2023	20/02/2023	Molecular and cellular biology, Methods and communication of results	Università degli Studi di Milano
08/06/2023	21/07/2023	Piccoli animali (roditori-zebrafish-xenopus): formazione specifica per il personale coinvolto nella sperimentazione animale per fini scientifici ii edizione (UZ0)	Università degli Studi di Milano
15/06/2023	16/06/2023	Noncoding RNA workshop	Università degli studi di Milano

Conferences / Workshops:

Starting Date	Ending Date	Title	Place
18/02/2023	22/02/2023	67th Biophysical Society Annual Meeting	San Diego (USA)
13/03/2023	15/03/2023	XXI Convention Telethon 2023	Riva del Garda (IT)
04/09/2023	08/09/2023	1st Single Molecule Biophysics course	Humboldt University - Berlin (DE)
05/10/2023	06/10/2023	2nd Channelopathy Meeting Tübingen	Online
23/05/2024	25/05/2024	Third International Workshop on High Frequency Oscillations in Epilepsy	NYU Langone Health, New York
06/07/2024	12/07/2024	Gordon Research Conference - Ion Channels	Mount Holyoke College, Massachusetts, United States
14/11/2024	14/11/2024	Special Biochemistry Seminar - Roberta Castelli	Saint Louis University, MO, USA
15/02/2025	19/02/2025	69th Biophysical Society Annual Meeting	Los Angeles (USA)
17/03/2025	19/03/2025	XXII Convention Telethon 2025	Rimini (IT)

Posters:

Date	Title	Place	File
20/02/2023	Nanobody-mediated modulation of HCN channels - oral presentation	BPS23 - San Diego (USA)
13/03/2023	Nanobody-mediated modulation of HCN1 channels in epileptic disorders	XXI Convention Telethon - Riva del garda (IT)
06/07/2024	HCN4 specific nanobody for the modulation of pathogenic channels	Gordon Research Conference
18/02/2025	HCN-specific nanobodies for the modulation of pathogenic channels	BPS2025 - Los Angeles (USA)
17/03/2025	Nanobody-mediated modulation of HCN1 channels in epileptic disorders	XXII Convention Telethon - Rimini (IT)

Abroad experiences:

Starting Date	Ending Date	Project	Institution	Supervisor
01/03/2024	03/03/2025	Novel therapeutic approaches emerging from HCN channels structural and functional studies	Columbia University - Zuckerman Mind Brain Behavior Institute (NYC)	Dr. Bina Santoro

Publications:

 A high affinity switch for cAMP in the HCN pacemaker channels
A. Porro, A. Saponaro, R. Castelli, B. Introini, A.H. Alkotob, G. Ranjbari, U. Enke, J. Kusch, K. Benndorf, B. Santoro, D. Difrancesco, G. Thiel, A. Moroni
Nature Communications

 Structural determinants of ivabradine block of the open pore of HCN4
A. Saponaro, J. H Krumbach, A. Chaves-Sanjuan, A. Sadat Sharifzadeh, A. Porro, R. Castelli, K. Hamacher, M. Bolognesi, D. DiFrancesco, O. B Clarke, G. Thiel, A. Moroni
PNAS