Roberta Castelli
Email: roberta.castelli@unimi.it
Cicle: XXXVIII A.Y. 2022 - 2023
Supervisor: Anna Moroni
Title: Novel therapeutic approaches emerging from HCN channels structural and functional studies … read more

External links: GoogleScholar Scopus ORCID

PhD Seminars:

Date	Title	Speakers
20/02/2023	How do you feel? The Molecules that Sense Touch	Ardem Patapoutian
21/02/2023	A nanobody toolkit for the regulation of K2P channel function	Stephen J. Tucker
21/02/2023	Potassium channel openers targeting different sites of the channel	Fredrik Elinder
14/03/2023	The CFTR corrector C17 is effective in sarcoglycanopathies: proof of concept and ADME studies	Dorianna Sandonà
15/03/2023	A functional genomics framework to investigate the molecular bases of rare genetic diseases	Davide Cacchiarelli
21/04/2023	Computational modeling: a quantitative tool to investigate cardiac cellular electrophysiology	Stefano Severi
06/09/2023	Unconventional approaches to single cell recordings	Claudio Grosman
07/09/2023	How can snails help us understand memory formation	Jelena Baranovic
08/09/2023	CaMKII activity spreads by inter-holoenzyme phosphorylation	Iva Lučić
05/10/2023	Molecule, cell, organism: multi-level analysis of a sick ion channel	Bina Santoro
05/10/2023	A small-molecule precision medicine for HCN1 DEE	Christopher Reid
13/03/2024	Rethinking the role of the piriform cortex in odor forming	Kevin Franks
11/04/2024	Minding what matters: philosophy in neuroscience	Paul Linton, John Morrison, Nedah Nemati
12/04/2024	Organization and control of hippocampal circuits	Ivan Soltesz

PhD Courses:

Starting Date	Ending Date	Title	Place
09/01/2023	31/01/2023	Biostatistics for Molecular and Cellular Biology	Università degli studi di Milano
13/02/2023	20/02/2023	Molecular and cellular biology, Methods and communication of results	Università degli Studi di Milano
08/06/2023	21/07/2023	Piccoli animali (roditori-zebrafish-xenopus): formazione specifica per il personale coinvolto nella sperimentazione animale per fini scientifici ii edizione (UZ0)	Università degli Studi di Milano
15/06/2023	16/06/2023	Noncoding RNA workshop	Università degli studi di Milano

Conferences / Workshops:

Starting Date	Ending Date	Title	Place
18/02/2023	22/02/2023	67th Biophysical Society Annual Meeting	San Diego (USA)
13/03/2023	15/03/2023	XXI Convention Telethon 2023	Riva del Garda (IT)
04/09/2023	08/09/2023	1st Single Molecule Biophysics course	Humboldt University - Berlin (DE)
05/10/2023	06/10/2023	2nd Channelopathy Meeting Tübingen	Online
23/05/2024	25/05/2024	Third International Workshop on High Frequency Oscillations in Epilepsy	NYU Langone Health, New York
06/07/2024	12/07/2024	Gordon Research Conference - Ion Channels	Mount Holyoke College, Massachusetts, United States

Posters:

Date	Title	Place	File
20/02/2023	Nanobody-mediated modulation of HCN channels - oral presentation	BPS23 - San Diego (USA)
13/03/2023	Nanobody-mediated modulation of HCN1 channels in epileptic disorders	XXI Convention Telethon - Riva del garda (IT)
06/07/2024	HCN4 specific nanobody for the modulation of pathogenic channels	Gordon Research Conference

Abroad experiences:

Starting Date	Ending Date	Project	Institution	Supervisor
01/03/2024	03/03/2025	Novel therapeutic approaches emerging from HCN channels structural and functional studies	Columbia University - Zuckerman Mind Brain Behavior Institute (NYC)	Dr. Bina Santoro

Publications:

 A high affinity switch for cAMP in the HCN pacemaker channels
A. Porro, A. Saponaro, R. Castelli, B. Introini, A.H. Alkotob, G. Ranjbari, U. Enke, J. Kusch, K. Benndorf, B. Santoro, D. Difrancesco, G. Thiel, A. Moroni
Nature Communications

 Structural determinants of ivabradine block of the open pore of HCN4
A. Saponaro, J. H Krumbach, A. Chaves-Sanjuan, A. Sadat Sharifzadeh, A. Porro, R. Castelli, K. Hamacher, M. Bolognesi, D. DiFrancesco, O. B Clarke, G. Thiel, A. Moroni
PNAS