Roberta Castelli
Email:
roberta.castelli@unimi.it
Cicle:
XXXVIII A.Y.
2022 - 2023
Supervisor:
Anna Moroni
Title:
Novel therapeutic approaches emerging from HCN channels structural and functional studies … read more
External links: GoogleScholar
Scopus
ORCID
PhD Seminars:
| Date |
Title |
Speakers |
| 20/02/2023 |
How do you feel? The Molecules that Sense Touch |
Ardem Patapoutian |
| 21/02/2023 |
A nanobody toolkit for the regulation of K2P channel function |
Stephen J. Tucker |
| 21/02/2023 |
Potassium channel openers targeting different sites of the channel |
Fredrik Elinder |
| 14/03/2023 |
The CFTR corrector C17 is effective in sarcoglycanopathies: proof of concept and ADME studies |
Dorianna Sandonà |
| 15/03/2023 |
A functional genomics framework to investigate the molecular bases of rare genetic diseases |
Davide Cacchiarelli |
| 21/04/2023 |
Computational modeling: a quantitative tool to investigate cardiac cellular electrophysiology |
Stefano Severi |
| 06/09/2023 |
Unconventional approaches to single cell recordings |
Claudio Grosman |
| 07/09/2023 |
How can snails help us understand memory formation |
Jelena Baranovic |
| 08/09/2023 |
CaMKII activity spreads by inter-holoenzyme phosphorylation |
Iva Lučić |
| 05/10/2023 |
Molecule, cell, organism: multi-level analysis of a sick ion channel |
Bina Santoro |
| 05/10/2023 |
A small-molecule precision medicine for HCN1 DEE |
Christopher Reid |
| 01/12/2023 |
Blocking channels to metastasis: targeting sodium transport in breast cancer |
William Brackenbury |
| 13/03/2024 |
Rethinking the role of the piriform cortex in odor forming |
Kevin Franks |
| 11/04/2024 |
Minding what matters: philosophy in neuroscience |
Paul Linton, John Morrison, Nedah Nemati |
| 12/04/2024 |
Organization and control of hippocampal circuits |
Ivan Soltesz |
| 02/07/2024 |
The dynamic structure of cognition |
André Fenton |
| 07/08/2024 |
Optogenetic mimicry to improve the circuit model of drug addiction |
Christian Lüscher |
| 13/08/2024 |
Mechanisms of hippocampal learning and memory |
Jeffrey Magee |
| 09/09/2024 |
Cell adhesion molecules control distinct spatiotemporal aspects of neuronal remodeling |
Oren Schuldiner |
| 10/09/2024 |
From genes to function: Leveraging genomic insights from the past decade toward understanding the etiology of severe psychiatric disorders |
Tarjinder (TJ) Singh |
| 14/10/2024 |
The electrophisiological signatures of naturalistic memory encoding |
Marta Silva |
| 23/10/2024 |
Evolution of telencephalic interneuron diversity across vertebrates |
Giacomo Gattoni |
| 06/11/2024 |
Dimensionality and dynamics of decision-making in simultaneous recordings from the hippocampus, prefrontal, and premotor cortex of virtually navigating macaques |
Roberto Gulli |
| 13/11/2024 |
Imaging genome organization and transcriptional regulation in live olfactory neurons |
Joan Pulupa |
| 10/12/2024 |
Electrical synapses act as a magnitude filter to modulate sensory information processing and behavioral choices in C. elegans |
Daniel Colón-Ramos |
| 15/01/2025 |
How does the brain read? An investigation of top-down control during visual word recognition |
Vassiki Chauhani |
| 21/01/2025 |
Applications of human PSCs in modeling and treating neural disease |
Lorenz Studer |
| 05/02/2025 |
A novel theory of information demand in the framework of probabilistic reasoning |
Matthew Jiwa |
| 15/02/2025 |
How to discover sequence to function relationships across multi-pass membrane proteome |
Willow Coyote-Maestas |
| 14/03/2025 |
Proton selective conductance and gating of lysosomal cation channel TMEM175 |
Oliver Rauh |
| 08/07/2025 |
Characterizing and exploiting allostery in G-protein coupled receptors |
Evan O'Brien |
PhD Courses:
| Starting Date |
Ending Date |
Title |
Place |
| 09/01/2023 |
31/01/2023 |
Biostatistics for Molecular and Cellular Biology |
Università degli studi di Milano |
| 13/02/2023 |
20/02/2023 |
Molecular and cellular biology, Methods and communication of results |
Università degli Studi di Milano |
| 08/06/2023 |
21/07/2023 |
Piccoli animali (roditori-zebrafish-xenopus): formazione specifica per il personale coinvolto nella sperimentazione animale per fini scientifici ii edizione (UZ0) |
Università degli Studi di Milano |
| 15/06/2023 |
16/06/2023 |
Noncoding RNA workshop |
Università degli studi di Milano |
| 07/04/2025 |
09/04/2025 |
New trends in efficient and sustainable preparation of high-value chemicals |
Università degli studi di Milano |
Conferences / Workshops:
| Starting Date |
Ending Date |
Title |
Place |
| 18/02/2023 |
22/02/2023 |
67th Biophysical Society Annual Meeting |
San Diego (USA) |
| 13/03/2023 |
15/03/2023 |
XXI Convention Telethon 2023 |
Riva del Garda (IT) |
| 04/09/2023 |
08/09/2023 |
1st Single Molecule Biophysics course |
Humboldt University - Berlin (DE) |
| 05/10/2023 |
06/10/2023 |
2nd Channelopathy Meeting Tübingen |
Online |
| 23/05/2024 |
25/05/2024 |
Third International Workshop on High Frequency Oscillations in Epilepsy |
NYU Langone Health, New York |
| 06/07/2024 |
12/07/2024 |
Gordon Research Conference - Ion Channels |
Mount Holyoke College, Massachusetts, United States |
| 14/11/2024 |
14/11/2024 |
Special Biochemistry Seminar - Roberta Castelli |
Saint Louis University, MO, USA |
| 15/02/2025 |
19/02/2025 |
69th Biophysical Society Annual Meeting |
Los Angeles (USA) |
| 17/03/2025 |
19/03/2025 |
XXII Convention Telethon 2025 |
Rimini (IT) |
| 11/09/2025 |
14/09/2025 |
40th Congress of the International Union of Physiological Sciences (IUPS 2025) |
Frankfurt (DE) |
Posters:
| Date |
Title |
Place |
File |
| 20/02/2023 |
Nanobody-mediated modulation of HCN channels - oral presentation |
BPS23 - San Diego (USA) |
|
| 13/03/2023 |
Nanobody-mediated modulation of HCN1 channels in epileptic disorders |
XXI Convention Telethon - Riva del garda (IT) |
|
| 06/07/2024 |
HCN4 specific nanobody for the modulation of pathogenic channels |
Gordon Research Conference |
|
| 18/02/2025 |
HCN-specific nanobodies for the modulation of pathogenic channels |
BPS2025 - Los Angeles (USA) |
|
| 17/03/2025 |
Nanobody-mediated modulation of HCN1 channels in epileptic disorders |
XXII Convention Telethon - Rimini (IT) |
|
| 13/09/2025 |
Nanobody-mediated modulation of HCN channels in cardiac and neuronal disorders |
IUPS 2025 - Frankfurt (DE) |
|
| 13/09/2025 |
Nanobody-mediated modulation of HCN channels in cardiac and neuronal disorders |
IUPS 2025 - Frankfurt (DE) |
|
Abroad experiences:
| Starting Date |
Ending Date |
Project |
Institution |
Supervisor |
| 01/03/2024 |
03/03/2025 |
Novel therapeutic approaches emerging from HCN channels structural and functional studies |
Columbia University - Zuckerman Mind Brain Behavior Institute (NYC) |
Dr. Bina Santoro |
Publications:
A high affinity switch for cAMP in the HCN pacemaker channelsA. Porro, A. Saponaro, R. Castelli, B. Introini, A.H. Alkotob, G. Ranjbari, U. Enke, J. Kusch, K. Benndorf, B. Santoro, D. Difrancesco, G. Thiel, A. Moroni
Nature Communications
Structural determinants of ivabradine block of the open pore of HCN4A. Saponaro, J. H Krumbach, A. Chaves-Sanjuan, A. Sadat Sharifzadeh, A. Porro, R. Castelli, K. Hamacher, M. Bolognesi, D. DiFrancesco, O. B Clarke, G. Thiel, A. Moroni
PNAS
Extracellular activation of HCN4 by a subtype-specific nanobodyA. S. Sharifzadeh#, R. Castelli#, A. Porro, P. Mesirca, R. Perrier, A. M. Gómez, N. Mekrane, H. Benoit, A.C. Meli, L. M. G. Palloni, D. DiFrancesco, M.E. Mangoni, G. Thiel, A. Saponaro, A. Moroni
Nature Communications
