Claudia Novello
Email: claudia.novello@unimi.it
Cicle: XXXVIII A.Y. 2022 - 2023
Supervisor: Graziella Cappelletti
Title: Alpha-synuclein aggregation: modulators and impact on gut-brain axis. … read more

PhD Seminars:

Date	Title	Speakers
04/11/2022	Ligand stimulating antitumor immunity as the next G-quadruplex challenge	Giovanni Capranico
17/11/2022	Genetic instability: from RNA to replication stress	Andrés Aguilera
24/11/2022	Transcriptional control of myeloid cell identity and activation	Renato Ostuni
31/01/2023	MITOCHONDRIA NETWORK AS A CENTRAL HUB IN THE CONTROL OF PROTEOSTASIS AND AGEING	Marco Sandri
28/03/2023	PINning down the role of prolyl isomerization in cancer and neurodegeneration.	Giannino Del Sal
05/04/2023	Hematopoietic stem/progenitor cell-gene therapy in inborns error of metabolism	Maria Ester Bernardo
05/05/2023	Tissue fluidification in pathophysiology	Giorgio Scita
09/05/2023	causes and consequences of DNA replication stress in cancer and stem cells	Vincenzo Costanzo
15/05/2023	Understanding biomolecular behaviour with mass photometry	Perla Vega Dominguez
04/07/2023	Molecular and functional heterogeneity in dorsal and ventral oligodendrocyte progenitor cells of the mouse forebrain in response to DNA damage	Prof. Enrica Boda
20/10/2023	Chaperone regulation of the protein condensation and aggregation continuum in Alzheimer's disease	Prof Claudio Gomes
03/11/2023	Conformational ensembles of the human intrinsically disordered proteome	Kresten Lindorff-Larsen
02/02/2024	What the structures of amyloids teach us about amyloid pathology	Joost Schymkowitz
01/03/2024	Ex vivo gene therapy for DMD: steps towards efficacy	Prof. Giulio Cossu
13/03/2024	From myogenesis to muscle wasting: uncovering new players and therapeutic approaches	Giorgia Careccia
04/04/2024	Cation transport system in bacteria and plant cells	Nobuyuki Uozumi
07/05/2024	Presentation of Massphotometry	Dilber Irmak
12/07/2024	Role of forces in membrane dynamics and liver tissue morphogenesis.	Marino Zerial
23/07/2024	Hacking the polyubiquitin code to control ion channel expression for therapy	Henry Colecraft
10/09/2024	Molecular Simulations for Molecular Design	Giorgio Colombo
28/10/2024	Accurate modeling DNA deformability and its role in protein binding	Martin Zacharias
21/03/2025	Recent Progress in IPS Cell Research and Application	Shinya Yamanaka
11/04/2025	Rewarding interactions - emerging patterns from cell polarity to microbial root colonization	Guido Grossmann
09/05/2025	Seeing glutamate at central synapses	Andrew Plested
23/06/2025	Parole, sguardi, abitudini: il genere nei luoghi della conoscenza	Gruppo di lavoro “Parità di genere” DBS
27/06/2025	Smart Scissors and Smarter Algorithms: Computational Biology and CRISPR vs. Cancer	Francesco Iorio
11/07/2025	RhoGTPases in human cancer cell dissemination and metastasis	Camilla Cerutti
18/07/2025	Shared Roots & Divergent Branches: studying in vivo lineage decisions in the developing spinal cord with genomic barcoding	Dr Giulia Boezio
16/09/2025	Control of fertility in plants: balancing reproduction and stress responses	Dr.ssa Silvia Manrique
26/09/2025	Investigating the role of LINE1 repeats’ transcription in health and disease	Dr. Cristina Tufarelli

PhD Courses:

Starting Date	Ending Date	Title	Place
11/12/2022	22/12/2022	Piccoli animali (roditori-zebrafish-xenopus): formazione specifica per il personale coinvolto nella sperimentazione animale per fini scientifici	Milano
22/03/2023	23/03/2023	Percorso formativo per funzione A Moduli 3.2 Biologia di Base - 6.2 Eutanasia - 8 Procedure minimamente invasive senza anestesia Specie topo	Stabilimento Utilizzatore di Charles River Italia
19/06/2023	22/06/2023	Host- pathogen interaction	Milano
09/11/2023	31/01/2023	Biostatistics for Molecular and Cellular Biology	Milano
26/02/2024	04/02/2024	method of communication and results	Milano

Conferences / Workshops:

Starting Date	Ending Date	Title	Place
25/11/2022	26/11/2022	GISN Gruppo Italiano per lo studio della neuromorfologia	Napoli
26/01/2023	27/01/2023	Precision Medicine in Parkinson’s Disease	Luxemburg
14/09/2023	17/09/2023	SINS neuroscience 20th national congress	Torino
25/11/2023	26/11/2023	GISN Gruppo Italiano per lo studio della neuromorfologia	Verona
10/06/2024	11/06/2024	19th Annual Meeting of GEoPD 2024	Milano
08/04/2025	08/04/2025	Synuclein Meeting 2025	Cambridge
10/09/2025	10/09/2025	SINS neuroscience 21th national congress_PhD meeting	Pisa

Posters:

Date	Title	Place	File
26/01/2023	PARYLATION OF α-SYNUCLEIN OLIGOMERS IN PARKINSON’S DISEASE PATIENTS: A TRIGGER FOR PROTEIN AGGREGATION	Luxemburg
25/11/2023	γ-PGA PROTECTIVE EFFECT IN A CELLULAR PD MODEL	Verona
10/06/2024	α-SYNUCLEIN OLIGOMERS AND SYNAPTIC DENSITY AS PERIPHERAL BIOMARKERS IN IDIOPATHIC AND GBA1-PARKINSON’S DISEASE	Milano
10/06/2025	Poly-γ-glutamic acid affects the clearance of pre-formed fibrils of α-synuclein and modulates inflammation in murine primary astrocytes	Cambridge
10/09/2025	Poly-γ-Glutamic Acid modulates α-Synuclein pathology and astrocyte inflammatory response	Pisa

Publications:

 Comparing GBA1‐Parkinson's disease and idiopathic Parkinson's disease: α‐Synuclein oligomers and synaptic density as biomarkers in the skin biopsy
Samanta Mazzetti, Elena Contaldi, Milo Jarno Basellini, Claudia Novello, Alessandra Maria Calogero, Letizia Straniero, Federica Garrì, Valentina Ferri, Daniela Calandrella, Francesca Del Sorbo, Rosanna Asselta, Emanuele Cereda, Graziella Cappelletti, Ioannis Ugo Isaias, Gianni Pezzoli
Brain Pathology

 Poly-γ-glutamic acid alleviates cytotoxicity and inflammation induced by pre-formed fibrils of α-synuclein in murine primary astrocytes
Claudia Novello, Mattia Parati, Samanta Mazzetti, Oriana Rampoldi, Huseyin Berkcan Isilgan, Milo Jarno Basellini, Chiara M G De Luca, Arianna Ciullini, Ilaria L Dellarole, Alessandro Fantin, Isabella Russo, Brian L Johnston, Moira Paroni, Chiara Rolando, Fabio Moda, Gianni Pezzoli, Iza K Radecka, Graziella Cappelletti
International Journal of Biological Maromolecules