www.unimi.it bioscienze.bio Dipartimento Bioscienze

GENOME BIOLOGY LAB


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In our lab we are interested in understanding the function of DNA repetitive elements in the epigenetic regulation of the transcriptional response of the cell. In particular, we are asking whether DNA repeats could influence the inter-individual variability between humans in terms of response to environmental cues, adaptation and predisposition to human diseases. DNA repeats cover almost 70% of the human genome, and their function was largely ignored for decades. Nevertheless, there are emerging evidences of the peculiar role of repeats in regulating the epigenome. The work of our team may provide important mechanistic information and novel interpretation of how specific non coding DNA functions may directly influence cellular processes, such as differentiation, genome integrity, cellular plasticity and disease. Ultimate goal is to demonstrate that evolutionary acquisition of such elaborated fine modulation of transcription represent an added value for mammalians, and humans in particular, to react to environment, adapt to stress, and eventually predispose to better or worse outcomes in disease progression. 




Foto docenteBeatrice Bodega

Associate Professor in Molecular Biology



Email: Beatrice.Bodega@unimi.it
Phones: 0200660302
Address: IV floor / tower A
Thesis available: Ask the teacher
Keywords: DNA repeats, Transposable elements, epigenetics, transcriptional regulation, genome organization and metabolism
Main topics of the group:
  1. Transposable Elements function in epigenetic regulation of cellular identity and function
  2. Repetitive Elements role in genome integrity and metabolism in health and disease


Foto docenteBeatrice Bodega

Associate Professor in Molecular Biology


Email: Beatrice.Bodega@unimi.it
Phones: 0200660302
Address: IV floor / tower A
Keywords: DNA repeats, Transposable elements, epigenetics, transcriptional regulation, genome organization and metabolism
Main topics of the group:
  1. Transposable Elements function in epigenetic regulation of cellular identity and function
  2. Repetitive Elements role in genome integrity and metabolism in health and disease




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